Name: ADA33 Polyclonal Antibody
SKU: WP0835
Price: 268 USD
Availability: InStock

ADA33 Polyclonal Antibody

Ucallm_WP0835-50

Price range: $268.00 through $328.00

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50μl

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SKU: WP0835-100

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Product details

Background:

ADAM metallopeptidase domain 33(ADAM33) Homo sapiens This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013],

Specifications

Target	ADA33
Reactivity	Human, Mouse
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	89kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:500-2000; ELISA 1:5000-20000
Formulation	Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
Source
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from human protein . at AA range: 200-280
Sequence
Specificity	ADA33 Polyclonal Antibody detects endogenous levels of protein.
Gene Name	ADAM33 C20orf153 UNQ873/PRO1891
Protein Name	Disintegrin and metalloproteinase domain-containing protein 33 (ADAM 33) (EC 3.4.24.-)
Other Name
Species	Human
Gene ID-1	80332
Uniprot	Q9BZ11,
Species.1	Mouse
Gene ID-2
Uniprot.1	Q923W9
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	ADAM metallopeptidase domain 33(ADAM33) Homo sapiens This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013],
Cellular Localization	Membrane; Single-pass type I membrane protein.
Tissue Expression	Expressed in all tissues, except liver, with high expression in placenta, lung, spleen and veins.
Signaling_pathway
Research Areas
Function	cofactor:Binds 1 zinc ion per subunit.,Disease:Defects in ADAM33 may be a cause of susceptibility to asthma.,Domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase M12B domain.,tissue specificity:Expressed in all tissues, except liver, with high expression in placenta, lung, spleen and veins.,
RRID

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ADA33 Polyclonal Antibody

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ADA33 Polyclonal Antibody

Product details

Specifications

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