Price range: $268.00 through $328.00
Background:
The enzyme encoded by this intronless gene is a beta-1, 3-galactosyltransferase found in the medial Golgi apparatus, where it catalyzes the transfer of galactose from UDP-galactose to substrates containing a terminal beta-linked galactose moiety. The encoded enzyme has a particular affinity for galactose-beta-1, 4-xylose found in the linker region of glycosamines. This enzyme is required for glycosaminoglycan synthesis. [provided by RefSeq, Jun 2013],
| Size | 50μL/100μL |
| Target | B3GT6 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 36kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 50-130 |
| Specificity | B3GT6 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | B3GALT6 |
| Protein Name | Beta-1,3-galactosyltransferase 6 (Beta-1,3-GalTase 6) (Beta3Gal-T6) (Beta3GalT6) (GAG GalTII) (Galactosyltransferase II) (Galactosylxylosylprotein 3-beta-galactosyltransferase) (UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6) |
| Other Name | |
| Species | Human |
| Gene ID | 126792 |
| Uniprot | Q96L58, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q91Z92 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein . |
| Tissue Expression | Ubiquitous. |
| Signaling_pathway | |
| Research Areas | >>Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate; / >>Glycosaminoglycan biosynthesis - heparan sulfate / heparin; / >>Metabolic pathways |
| Function | Catalytic activity:UDP-galactose + 4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein.,Caution:PubMed:9892646 describes the wrong protein; the cDNAs used had been switched inadvertently.,cofactor:Manganese.,Function:Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues.,online information:Beta-1,3-galactosyltransferase 6,online information:GlycoGene database,pathway:Glycan metabolism; chondroitin sulfate biosynthesis.,pathway:Glycan metabolism; heparan sulfate biosynthesis.,similarity:Belongs to the glycosyltransferase 31 family.,tissue specificity:Ubiquitous., |
