SKU: WP1018 Categories: ,

CHD6 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP1018-100
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Product details

Background:

This gene encodes a member of the SNF2/RAD54 helicase protein family. The encoded protein contains two chromodomains, a helicase domain, and an ATPase domain. Several multi-subunit protein complexes remodel chromatin to allow patterns of cell type-specific gene expression, and the encoded protein is thought to be a core member of one or more of these chromatin remodeling complexes. The encoded protein may function as a transcriptional repressor and is involved in the cellular repression of influenza virus replication. [provided by RefSeq, Jul 2013],

Specifications

Size50μL/100μL
TargetCHD6
ReactivityHuman, Mouse, Rat
ApplicationsIHC, IF
MW(Calculated)
MW(Observed)298kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:50-300; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein
SpecificityCHD6 Polyclonal Antibody detects endogenous levels of protein.
Gene NameCHD6 CHD5 KIAA1335 RIGB
Protein NameChromodomain-helicase-DNA-binding protein 6 (CHD-6) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein)
Other Name
SpeciesHuman
Gene ID84181
UniprotQ8TD26
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationNucleus, nucleoplasm . Enriched at sites of mRNA synthesis (PubMed:17027977). During influenza A virus infection, localizes to inactive chromatin. .
Tissue ExpressionWidely expressed.
Signaling_pathway
Research Areas
FunctionFunction:Probable transcription regulator.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence Caution:The sequence differs from position 1528 onward for unknown reasons.,similarity:Belongs to the SNF2/RAD54 helicase family.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,similarity:Contains 2 chromo domains.,tissue specificity:Ubiquitous.,
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