Price range: $268.00 through $328.00
Background:
The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | GEM |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 32kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | GEM Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | GEM KIR |
| Protein Name | GTP-binding protein GEM (GTP-binding mitogen-induced T-cell protein) (RAS-like protein KIR) |
| Other Name | |
| Species | Human |
| Gene ID | 2669 |
| Uniprot | P55040, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P55041 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Peripheral membrane protein; Cytoplasmic side. |
| Tissue Expression | Most abundant in thymus, spleen, kidney, lung, and testis. Less abundant in heart, brain, liver and skeletal muscle. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.,induction:By mitogens.,PTM:Phosphorylated on tyrosine residues.,similarity:Belongs to the small GTPase superfamily. RGK family.,subunit:Interacts with calmodulin in a Ca(2+)-dependent manner. Binds ROCK1.,tissue specificity:Most abundant in thymus, spleen, kidney, lung, and testis. Less abundant in heart, brain, liver and skeletal muscle., |
