Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | CCNK |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 63kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 80-160 |
| Specificity | CCNK Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | CCNK CPR4 |
| Protein Name | Cyclin-K |
| Other Name | |
| Species | Human |
| Gene ID | 8812 |
| Uniprot | O75909, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | O88874 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . |
| Tissue Expression | Widely expressed. Highest levels in testis. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:May play a role in transcriptional regulation. In vitro, is associated with a kinase activity toward both RNA polymerase II C-terminal domain and CDK2 (CAK).,similarity:Belongs to the cyclin family. Cyclin C subfamily.,subunit:Part of a cyclin-kinase pair in the RNA polymerase II holoenzyme. Binds to CDK9.,tissue specificity:Ubiquitously expressed. Highest levels in testis., |
