Name: U-Blot® CDC37 (Phospho Ser13) Rabbit mAb
SKU: WR4012
Price: 288 USD
Availability: InStock

U-Blot® CDC37 (Phospho Ser13) Rabbit mAb

WR4012

Immunohistochemical analysis of paraffin-embedded rat brain tissue. 1, primary Antibody was diluted at 1:200(4～C,overnight). 2, EDTA pH 9.0 was used for antibody retrieval(>98～C,20min). 3,Secondary antibody was diluted at 1:200(room tempeRature, 30min).

WR4012 Immunohistochemical analysis of paraffin-embedded rat brain tissue. 1, primary Antibody was diluted at 1:200(4～C,overnight). 2, EDTA pH 9.0 was used for antibody retrieval(>98～C,20min). 3,Secondary antibody was diluted at 1:200(room tempeRature, 30min).

Immunohistochemical analysis of paraffin-embedded mouse brain tissue. 1, primary Antibody was diluted at 1:200(4～C,overnight). 2, EDTA pH 9.0 was used for antibody retrieval(>98～C,20min). 3,Secondary antibody was diluted at 1:200(room tempeRature, 30min).

WR4012 Immunohistochemical analysis of paraffin-embedded mouse brain tissue. 1, primary Antibody was diluted at 1:200(4～C,overnight). 2, EDTA pH 9.0 was used for antibody retrieval(>98～C,20min). 3,Secondary antibody was diluted at 1:200(room tempeRature, 30min).

Western blot analysis of lysates from PC-12 cells, using CDC37 (p-Ser13) Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.

WR4012 Western blot analysis of lysates from PC-12 cells, using CDC37 (p-Ser13) Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.

Price range: $288.00 through $368.00

Size

100μl

50μl

Clear

SKU: WR4012-50

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Product details

Background:The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	Cdc37 Phospho Ser13
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, IP, ELISA
MW(Calculated)	44kD
MW(Observed)	44kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	phosphate
Recommended Dilution Ratio	IHC 1:400-1000; WB 1:1000-5000; IF 1:200-1000; ELISA 1:5000-20000; IP 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM0060R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	This antibody detects endogenous levels of CDC37 only when phosphorylated at Ser13.
Gene Name	CDC37
Protein Name	Hsp90 co-chaperone Cdc37
Other Name	CDC37; / CDC37A; / Hsp90 co-chaperone Cdc37; / Hsp90 chaperone protein kinase-targeting subunit; / p50Cdc37
Species	Human
Gene ID	11140
Uniprot	Q16543,
Species.1	Mouse
Gene ID.1	12539
Uniprot.1	Q61081,
Species.2	Rat
Gene ID.2	114562
Uniprot.2	Q63692
Cellular Localization	Cytoplasm
Tissue Expression	Lymph,Placenta,
Signaling_pathway	Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Research Areas	>>PI3K-Akt signaling pathway
Function	Function:Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.,PTM:Constitutively sumoylated by UBE2I.,similarity:Belongs to the CDC37 family.,subunit:Forms a complex with Hsp90. Interacts with AR, CDK4, CDK6, EIF2AK1 and RB1.,