Product details

Background:

domain:Binds to transcription factors via its WW domain., domain:The PDZ-binding motif is essential for stimulated gene transcription. It localizes the protein into both punctate nuclear foci and plasma membrane-associated complexes., function:Functions as a transcriptional coactivator., PTM:Phosphorylated. Phosphorylation results in the inhibition of transcriptional coactivation through YWHAZ-mediated nuclear export., similarity:Contains 1 WW domain., subcellular location:Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ., subunit:Binds to SLC9A3R2 via the PDZ motif at the plasma membrane. Binds to YWHAZ in vivo and in vitro through the phosphoserine-binding motif RSHSSP., tissue specificity:Highly expressed in kidney, heart, placenta and lung.,

Specifications

Target	TAZ
Reactivity	Human, Mouse
Applications	WB, IHC
MW(Calculated)
MW(Observed)	50kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:500-2000; ELISA 1:5000-20000
Formulation	Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
Source
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from part region of human protein
Sequence
Specificity	WWTR1 Polyclonal Antibody detects endogenous levels of protein.
Gene Name	WWTR1 TAZ
Protein Name	WW domain-containing transcription regulator protein 1
Other Name	WW domain-containing transcription regulator protein 1; / Transcriptional coactivator with PDZ-binding motif
Species	Human
Gene ID-1	25937
Uniprot	Q9GZV5,
Species.1	Mouse
Gene ID-2	97064
Uniprot.1	Q9EPK5
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	domain:Binds to transcription factors via its WW domain.,domain:The PDZ-binding motif is essential for stimulated gene transcription. It localizes the protein into both punctate nuclear foci and plasma membrane-associated complexes.,function:Functions as a transcriptional coactivator.,PTM:Phosphorylated. Phosphorylation results in the inhibition of transcriptional coactivation through YWHAZ-mediated nuclear export.,similarity:Contains 1 WW domain.,subcellular location:Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ.,subunit:Binds to SLC9A3R2 via the PDZ motif at the plasma membrane. Binds to YWHAZ in vivo and in vitro through the phosphoserine-binding motif RSHSSP.,tissue specificity:Highly expressed in kidney, heart, placenta and lung.,
Cellular Localization	Nucleus . Cytoplasm . Cell membrane . Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies (By similarity). When phosphorylated, is retained in the cytoplasm by YWHAZ (By similarity). Can be retained in the nucleus by MED15 (PubMed:18568018). Localized in the cytoplasm in areas of epithelial cell high density (PubMed:21145499). At blastocyst stage expressed in the nucleus in trophectodermal cells, however expressed in the cytoplasm in the inner cell mass (By similarity). .
Tissue Expression	Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue.
Signaling_pathway	Environmental Information Processing >> Signal transduction >> Hippo signaling pathway;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway - multiple species
Research Areas	>>Hippo signaling pathway; / >>Hippo signaling pathway - multiple species
Function	Domain:Binds to transcription factors via its WW domain.,Domain:The PDZ-binding motif is essential for stimulated gene transcription. It localizes the protein into both punctate nuclear foci and plasma membrane-associated complexes.,Function:Functions as a transcriptional coactivator.,PTM:Phosphorylated. Phosphorylation results in the inhibition of transcriptional coactivation through YWHAZ-mediated nuclear export.,similarity:Contains 1 WW domain.,subcellular location:Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ.,subunit:Binds to SLC9A3R2 via the PDZ motif at the plasma membrane. Binds to YWHAZ in vivo and in vitro through the phosphoserine-binding motif RSHSSP.,tissue specificity:Highly expressed in kidney, heart, placenta and lung.,
RRID

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WWTR1 Polyclonal Antibody

Product details

Specifications

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WWTR1 Polyclonal Antibody

Product details

Specifications

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