Price range: $268.00 through $328.00
Background:
The protein encoded by this gene regulates the DNA damage response through several different signaling pathways. One such pathway is the p53-HDM2-p21(WAF1) pathway, which is critical to the DNA damage response. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015],
| Size | 50μL/100μL |
| Target | CARF |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 63kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | CARF Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | CDKN2AIP CARF |
| Protein Name | CDKN2A-interacting protein (Collaborator of ARF) |
| Other Name | |
| Species | Human |
| Gene ID | 55602 |
| Uniprot | Q9NXV6, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8BI72, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q5U2X0 |
| Cellular Localization | Nucleus, nucleoplasm . |
| Tissue Expression | Ubiquitously expressed. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Activates TP53/p53 by CDKN2A-dependent and CDKN2A-independent pathways.,PTM:May be ubiquitinated.,similarity:Belongs to the CARF family.,similarity:Contains 1 DRBM (double-stranded RNA-binding) domain.,subunit:Interacts with CDKN2A/p14ARF, TP53/p53 and MDM2.,tissue specificity:Ubiquitously expressed., |
