Price range: $268.00 through $328.00
Background:
T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).[supplied by OMIM, Mar 2008],
| Size | 50μL/100μL |
| Target | HSH2D |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 38kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human HSH2D AA range: 288-338 |
| Specificity | This antibody detects endogenous levels of HSH2D at Human/Mouse |
| Gene Name | HSH2D ALX |
| Protein Name | HSH2D |
| Other Name | Hematopoietic SH2 domain-containing protein; / Hematopoietic SH2 protein; / Adaptor in lymphocytes of unknown function X |
| Species | Human |
| Gene ID | 84941 |
| Uniprot | Q96JZ2, |
| Species.1 | Mouse |
| Gene ID.1 | 209488 |
| Uniprot.1 | Q6VYH9 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm. Nucleus. |
| Tissue Expression | Predominantly expressed in spleen and hematopoietic cells such as peripheral blood leukocytes and weakly expressed in prostate, thymus, heart, small intestine and placenta. |
| Signaling_pathway | |
| Research Areas | |
| Function | Caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,Function:May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter.,PTM:May be phosphorylated by FES and ACK1.,similarity:Contains 1 SH2 domain.,subunit:Interacts with FES and TNK2.,tissue specificity:Predominantly expressed in spleen and hematopoietic cells such as peripheral blood leukocytes and weakly expressed in prostate, thymus, heart, small intestine and placenta., |
