Price range: $268.00 through $328.00
Background:
This gene encodes a member of the importin-beta family of nuclear transport proteins. The encoded protein mediates the import of specific cargo proteins from the cytoplasm to the nucleus and is dependent on the Ras-related nuclear protein-GTPase system. The encoded protein is also involved in nuclear export of the eukaryotic translation initiation factor 1A.[provided by RefSeq, Mar 2009],
| Size | 50μL/100μL |
| Target | IPO13 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 105kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human IPO13 AA range: 484-534 |
| Specificity | This antibody detects endogenous levels of IPO13 at Human/Mouse/Rat |
| Gene Name | IPO13 KIAA0724 RANBP13 |
| Protein Name | IPO13 |
| Other Name | Importin-13; / Imp13; / Karyopherin-13; / Kap13; / Ran-binding protein 13; / RanBP13 |
| Species | Human |
| Gene ID | 9670 |
| Uniprot | O94829, |
| Species.1 | Mouse |
| Gene ID.1 | 230673 |
| Uniprot.1 | Q8K0C1, |
| Species.2 | Rat |
| Gene ID.2 | 116458 |
| Uniprot.2 | Q9JM04 |
| Cellular Localization | Cytoplasm. Nucleus. |
| Tissue Expression | Expressed in fetal brain, heart, intestine and kidney. |
| Signaling_pathway | Genetic Information Processing >> Translation >> Nucleocytoplasmic transport |
| Research Areas | >>Nucleocytoplasmic transport |
| Function | Function:Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.,similarity:Belongs to the importin beta family.,similarity:Contains 1 importin N-terminal domain.,similarity:Contains 14 HEAT repeats.,subunit:Interacts with UBC9, RBM8A, eIF-1A and PAX6.,tissue specificity:Expressed in fetal brain, heart, intestine and kidney., |
