Name: TRPC6 rabbit pAb
SKU: WP4446
Price: 268 USD
Availability: InStock

TRPC6 rabbit pAb

Ucallm_WP4446-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP4446-100

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Product details

Background:

The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009],

Specifications

Size	50μL/100μL
Target	TRPC6
Reactivity	Human, Mouse
Applications	WB
MW(Calculated)	102kD
MW(Observed)
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from human TRPC6 AA range: 412-462
Specificity	This antibody detects endogenous levels of TRPC6 at Human/Mouse
Gene Name	TRPC6 TRP6
Protein Name	TRPC6
Other Name
Species	Human
Gene ID	7225
Uniprot	Q9Y210,
Species.1	Mouse
Gene ID.1	22068
Uniprot.1	Q61143
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cell membrane; Multi-pass membrane protein .
Tissue Expression	Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm.
Signaling_pathway	Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway
Research Areas	>>cGMP-PKG signaling pathway; / >>Axon guidance
Function	Disease:Defects in TRPC6 are the cause of focal segmental glomerulosclerosis 2 (FSGS2) [MIM:603965]. FSGS2 is an autosomal dominant disease characterized by increased urinary protein excretion (proteinuria) and decreasing kidney function (nephrotic syndrome). Renal insufficiency often progresses to end-stage renal disease (ESRD) (also known as end-stage renal failure), a highly morbid state requiring either dialysis therapy or kidney transplantation.,Function:Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.,similarity:Belongs to the transient receptor family. STrpC subfamily.,similarity:Contains 4 ANK repeats.,subunit:Interacts with MX1 and RNF24.,tissue specificity:Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm.,

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TRPC6 rabbit pAb

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TRPC6 rabbit pAb

Product details

Specifications

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