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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/AT10A rabbit pAb
SKU: WP4517 Categories: ,

AT10A rabbit pAb

Ucallm_WP4517-50

Price range: $268.00 through $328.00

SKU: WP4517-100
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Product details

Background:

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene is maternally expressed. It maps within the most common interval of deletion responsible for Angelman syndrome, also known as 'happy puppet syndrome'. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetAT10A
ReactivityHuman, Mouse
ApplicationsWB
MW(Calculated)165kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human AT10A AA range: 1129-1179
SpecificityThis antibody detects endogenous levels of AT10A at Human/Mouse
Gene NameATP10A ATP10C ATPVA ATPVC KIAA0566
Protein NameAT10A
Other Name
SpeciesHuman
Gene ID57194
UniprotO60312,
Species.1Mouse
Gene ID.111982
Uniprot.1O54827
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCell membrane; Multi-pass membrane protein . Endoplasmic reticulum membrane . Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B.
Tissue ExpressionWidely expressed, with highest levels in kidney, followed by lung, brain, prostate, testis, ovary and small intestine.
Signaling_pathway
Research Areas
FunctionCatalytic activity:ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out).,Disease:Defects in ATP10A are a cause of Angelman syndrome (AS) [MIM:105830]; also known as 'happy puppet syndrome'. AS is characterized by features of severe motor and intellectual retardation, microcephaly, ataxia, frequent jerky limb movements and flapping of the arms and hands, hypotonia, hyperactivity, hypopigmentation, seizures, absence of speech, frequent smiling and episodes of paroxysmal laughter, and an unusual facies characterized by macrostomia, a large mandible and open-mouthed expression, a great propensity for protruding the tongue ('tongue thrusting'), and an occipital groove.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the cation transport ATPase (P-type) family. Type IV subfamily.,tissue specificity:Widely expressed, with highest levels in kidney, followed by lung, brain, prostate, testis, ovary and small intestine.,
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