Name: TF Polyclonal Antibody
SKU: WP5805
Price: 268 USD
Availability: InStock

TF Polyclonal Antibody

Ucallm_WP5805-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP5805-100

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Product details

Background:

transferrin(TF) Homo sapiens This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009],

Specifications

Size	50μL/100μL
Target	Transferrin
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF
MW(Calculated)
MW(Observed)	77kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-10000; IHC 1:200-500; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from part region of human protein AA range: 230-310
Specificity	The antibody detects endogenous TF protein.
Gene Name	TF
Protein Name	Serotransferrin
Other Name	TF; / Serotransferrin; / Transferrin; / Beta-1 metal-binding globulin; / Siderophilin
Species	Human
Gene ID	7018
Uniprot	P02787,
Species.1	Mouse
Gene ID.1	22041
Uniprot.1	Q921I1,
Species.2	Rat
Gene ID.2	24825
Uniprot.2	P12346
Cellular Localization	Secreted.
Tissue Expression	Expressed by the liver and secreted in plasma.
Signaling_pathway	Cellular Processes >> Cell growth and death >> Ferroptosis;Environmental Information Processing >> Signal transduction >> TGF-beta signaling pathway;Environmental Information Processing >> Signal transduction >> HIF-1 signaling pathway
Research Areas	>>HIF-1 signaling pathway; / >>Ferroptosis; / >>Mineral absorption
Function	Disease:Defects in TF are the cause of atransferrinemia [MIM:209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.,Function:Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.,online information:Transferrin entry,polymorphism:Different polymorphic variants of transferrin are known. The sequence shown is the predominant electrophoretic variant (C1 or TF*C1).,similarity:Belongs to the transferrin family.,similarity:Contains 2 transferrin-like domains.,subunit:Monomer.,tissue specificity:Expressed by the liver and secreted in plasma.,

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TF Polyclonal Antibody

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TF Polyclonal Antibody

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