Name: ATG7 Rabbit Polyclonal Antibody
SKU: WP5912
Price: 268 USD
Availability: InStock

ATG7 Rabbit Polyclonal Antibody

Ucallm_WP5912-50

Price range: $268.00 through $328.00

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50μl

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SKU: WP5912-100

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Product details

Background:

This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],

Specifications

Size	50μL/100μL
Target	APG7
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF
MW(Calculated)
MW(Observed)	78kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:50-300; WB 1:500-2000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Recombinant Protein of ATG7
Specificity	The antibody detects endogenous ATG7 protein
Gene Name	ATG7 APG7L
Protein Name	Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7) (Autophagy-related protein 7) (APG7-like) (hAGP7) (Ubiquitin-activating enzyme E1-like protein)
Other Name	Ubiquitin-like modifier-activating enzyme ATG7; / ATG12-activating enzyme E1 ATG7; / Autophagy-related protein 7; / APG7-like; / hAGP7; / Ubiquitin-activating enzyme E1-like protein
Species	Human
Gene ID	10533
Uniprot	O95352,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q9D906,
Species.2	Rat
Gene ID.2
Uniprot.2	Q641Y5
Cellular Localization	Cytoplasm . Preautophagosomal structure . Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. .
Tissue Expression	Widely expressed, especially in kidney, liver, lymph nodes and bone marrow.
Signaling_pathway	Cellular Processes >> Transport and catabolism >> Autophagy - animal;Cellular Processes >> Cell growth and death >> Ferroptosis;Organismal Systems >> Immune system >> Neutrophil extracellular trap formation
Research Areas	>>Autophagy - other; / >>Autophagy - animal; / >>Ferroptosis; / >>Neutrophil extracellular trap formation
Function	Domain:The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12.,Function:Functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. Forms intermediate conjugates with GABARAPL1 (GABARAPL2, GABARAP or MAP1ALC3). Formation of the final GABARAPL1-PE conjugate is essential for autophagy.,similarity:Belongs to the ATG7 family.,subunit:Homodimer (By similarity). Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5.,tissue specificity:Widely expressed, especially in kidney, liver, lymph nodes and bone marrow.,

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ATG7 Rabbit Polyclonal Antibody

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ATG7 Rabbit Polyclonal Antibody

Product details

Specifications

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