Product details
Background:
ACTN4 rabbit pAb
Ucallm_WP6065-50
Price range: $268.00 through $328.00
Specifications
| Target | ACTN4 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 100kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ACTN4 |
| Sequence | |
| Specificity | This antibody detects endogenous levels of ACTN4 at Human, Mouse,Rat |
| Gene Name | ACTN4 |
| Protein Name | Alpha-actinin-4 (F-actin cross-linking protein) (Non-muscle alpha-actinin 4) |
| Other Name | |
| Species | Human |
| Gene ID-1 | 81 |
| Uniprot | O43707, |
| Species.1 | Mouse |
| Gene ID-2 | 60595 |
| Uniprot.1 | P57780, |
| Species.2 | Rat |
| Gene ID-3 | 63836 |
| Uniprot.2 | Q9QXQ0 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | |
| Cellular Localization | Nucleus . Cytoplasm . Cell junction . Cytoplasm, cytoskeleton, stress fiber . Cytoplasm, perinuclear region . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Expressed in the perinuclear rim and manchette structure in early elongating spermatids during spermiogenesis (By similarity). Nuclear translocation can be induced by the PI3 kinase inhibitor wortmannin or by cytochalasin D. Exclusively localized in the nucleus in a limited number of cell lines (breast cancer cell line MCF-7, oral floor cancer IMC-2, and bladder cancer KU-7). . |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion;Cellular Processes >> Cellular community - eukaryotes >> Adherens junction;Cellular Processes >> Cellular community - eukaryotes >> Tight junction;Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Organismal Systems >> Immune system >> Leukocyte transendothelial migration;Human Diseases >> Immune disease >> Systemic lupus erythematosus |
| Research Areas | |
| Function | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation . Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA . |
| RRID |
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