Product details
Background:
EED rabbit pAb
Ucallm_WP6138-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | EED |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 49kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human EED |
| Specificity | This antibody detects endogenous levels of EED at Human, Mouse |
| Gene Name | EED |
| Protein Name | Polycomb protein EED (hEED) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1) |
| Other Name | |
| Species | Human |
| Gene ID | 8726 |
| Uniprot | O75530, |
| Species.1 | Mouse |
| Gene ID.1 | 13626 |
| Uniprot.1 | Q921E6 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus. Chromosome. Transiently colocalizes with XIST at inactive X chromosomes. |
| Tissue Expression | Expressed in brain, colon, heart, kidney, liver, lung, muscle, ovary, peripheral blood leukocytes, pancreas, placenta, prostate, spleen, small intestine, testis, thymus and uterus. Appears to be overexpressed in breast and colon cancer. |
| Signaling_pathway | |
| Research Areas | |
| Function | Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. |
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