Product details
Background:
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ERCC6L rabbit pAb
Ucallm_WP6611-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | ERCC6L |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 138kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ERCC6L |
| Specificity | This antibody detects endogenous levels of ERCC6L at Human, Mouse |
| Gene Name | ERCC6L PICH |
| Protein Name | DNA excision repair protein ERCC-6-like (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) |
| Other Name | |
| Species | Human |
| Gene ID | 54821 |
| Uniprot | Q2NKX8, |
| Species.1 | Mouse |
| Gene ID.1 | 236930 |
| Uniprot.1 | Q8BHK9 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Chromosome, centromere . Chromosome, centromere, kinetochore . Chromosome . Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase. In prometaphase cells, it mostly concentrates in between kinetochores. In metaphase, it localizes to numerous thin threads that stretch between sister kinetochores of the aligned chromosomes and are composed of catenated centromeric DNA. Evolution from inner centromeres to thin threads takes place in response to tension. Resolution of thin threads requires topoisomerase 2-alpha (TOP2A) after anaphase onset. . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase . Functions as ATP-dependent DNA translocase . Can promote Holliday junction branch migration (in vitro) . |
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