Product details
Background:
THG1L rabbit pAb
Ucallm_WP7334-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | THG1L |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 33kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human THG1L |
| Specificity | This antibody detects endogenous levels of THG1L at Human, Mouse,Rat |
| Gene Name | THG1L ICF45 |
| Protein Name | Probable tRNA(His) guanylyltransferase (Interphase cytoplasmic foci protein 45) (tRNA-histidine guanylyltransferase) |
| Other Name | |
| Species | Human |
| Gene ID | 54974 |
| Uniprot | Q9NWX6, |
| Species.1 | Mouse |
| Gene ID.1 | 66628 |
| Uniprot.1 | Q9CY52, |
| Species.2 | Rat |
| Gene ID.2 | 303067 |
| Uniprot.2 | Q5M965 |
| Cellular Localization | Cytoplasm . Mitochondrion outer membrane . |
| Tissue Expression | Expressed in many tissues. |
| Signaling_pathway | |
| Research Areas | |
| Function | Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis (Probable). Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion . By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress . |
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