Product details
Background:
ZNF207 rabbit pAb
Ucallm_WP8494-50
Price range: $268.00 through $328.00
Specifications
| Target | ZNF207 |
| Reactivity | Human |
| Applications | WB |
| MW(Calculated) | 53kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ZNF207 |
| Sequence | |
| Specificity | This antibody detects endogenous levels of ZNF207 at Human |
| Gene Name | ZNF207 |
| Protein Name | Zinc finger protein 207 |
| Other Name | |
| Species | Human |
| Gene ID-1 | 7756 |
| Uniprot | O43670 |
| Species.1 | |
| Gene ID-2 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID-3 | |
| Uniprot.2 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | |
| Cellular Localization | Nucleus . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle . Localizes primarily to the nucleus in interphase, concentrates at kinetochores prior to nuclear envelope breakdown and during early prometaphase, and disappears from kinetochores upon microtubule-binding. . |
| Tissue Expression | Ubiquitous. |
| Signaling_pathway | |
| Research Areas | |
| Function | Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly . ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks . Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 . Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 . According to another report, the stabilization is independent of the proteasome . |
| RRID |
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