Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010],
| Size | 50μL/100μL |
| Target | ATG16L1 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 70kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:5000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from Atg16 . at AA range: 60-140 |
| Specificity | Atg16 Polyclonal Antibody detects endogenous levels of Atg16 protein. |
| Gene Name | ATG16L1 |
| Protein Name | Autophagy-related protein 16-1 |
| Other Name | ATG16L1; / APG16L; / Autophagy-related protein 16-1; / APG16-like 1 |
| Species | Human |
| Gene ID | 55054 |
| Uniprot | Q676U5, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8C0J2 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Preautophagosomal structure membrane; Peripheral membrane protein . Endosome membrane; Peripheral membrane protein . Lysosome membrane; Peripheral membrane protein . Recruited to omegasomes membranes by WIPI2 (By similarity). Omegasomes are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures (By similarity). Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5 (By similarity). Localizes also to discrete punctae along the ciliary axoneme (By similarity). Upon activation of non-canonical autophagy, recruited to single-membrane endolysosomal compartments (PubMed:29317426). . |
| Tissue Expression | Brain,Colon,Epithelium,Fetal brain,Human lung,Mammary gland,Placenta,Small |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Autophagy - animal;Organismal Systems >> Immune system >> NOD-like receptor signaling pathway |
| Research Areas | >>Autophagy - other; / >>Autophagy - animal; / >>NOD-like receptor signaling pathway; / >>Shigellosis |
| Function | Disease:Genetic variations in ATG16L1 are associated with susceptibility to inflammatory bowel disease type 10 (IBD10) [MIM:611081]. IBD is characterized by a chronic relapsing intestinal inflammation. IBD is subdivided into Crohn disease (CD) and ulcerative colitis phenotypes. IBD10 individuals show the phenotype characteristic to CD. It may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. CD is commonly classified as autoimmune disease.,Function:Plays an essential role in autophagy.,sequence Caution:Wrong choice of CDS.,similarity:Belongs to the WD repeat ATG16 family.,similarity:Contains 7 WD repeats.,subcellular location:Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5.,subunit:Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa)., |
