Product details

Background:

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identi

Specifications

Size	50μL/100μL
Target	ATP5G3
Reactivity	Human, Rat
Applications	IHC, IF, ELISA
MW(Calculated)	15kD
MW(Observed)
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human ATP5G3. AA range:1-50
Specificity	ATP5G3 Polyclonal Antibody detects endogenous levels of ATP5G3 protein.
Gene Name	ATP5G3
Protein Name	ATP synthase lipid-binding protein mitochondrial
Other Name	ATP5G3; / ATP synthase lipid-binding protein; / mitochondrial; / ATP synthase proteolipid P3; / ATPase protein 9; / ATPase subunit c
Species	Human
Gene ID	518
Uniprot	P48201,
Species.1	Mouse
Gene ID.1
Uniprot.1	P56384,
Species.2	Rat
Gene ID.2	114630
Uniprot.2	Q71S46
Cellular Localization	Mitochondrion membrane; Multi-pass membrane protein.
Tissue Expression	Liver,Subthalamic nucleus,
Signaling_pathway	Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Parkinson disease;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Huntington disease;Human Diseases >> Neurodegenerative disease >> Prion disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
Research Areas	>>Oxidative phosphorylation; / >>Metabolic pathways; / >>Thermogenesis; / >>Alzheimer disease; / >>Parkinson disease; / >>Amyotrophic lateral sclerosis; / >>Huntington disease; / >>Prion disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Chemical carcinogenesis - reactive oxygen species; / >>Diabetic cardiomyopathy
Function	Disease:This protein is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).,Function:Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.,miscellaneous:There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins.,similarity:Belongs to the ATPase C chain family.,subunit:F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.,subunit:F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.,

Please login to post questions

ATP5G3 Polyclonal Antibody

Product details

Specifications

About Us

Support

Order

Menu

ATP5G3 Polyclonal Antibody

Product details

Specifications

Related products

U-Blot® PMS2 Rabbit mAb

U-Blot® CDK6 Rabbit mAb

U-Blot® VEGF Receptor 1 Rabbit mAb

Acetyl Lysine Monoclonal Antibody [10B10]

U-Blot® GSK3 β (Phospho Ser9) Rabbit mAb

U-Blot® FOXO3A (Phospho Ser253) Rabbit mAb

Customer Reviews

Menu