Name: Centriolin Polyclonal Antibody
SKU: WP11578
Price: 268 USD
Availability: InStock

Centriolin Polyclonal Antibody

Ucallm_WP11578-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP11578-100

Enter the quantity you would like, or drag the panel to find the quantity and price that best for you

Bulk Quote Authorize OEM & ODM

Product details

Background:

function:Necessary for centrosome duplication. Collaborates with CEP97, being involved in the suppression of a cilia assembly program. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2., induction:Up-regulated during the transition from G1 to S phase of the cell cycle. The highest levels are observed in S phase, after which the levels decrease markedly., PTM:Phosphorylated by CDKs., subunit:Interacts with CALM1, CETN2 and CEP97., tissue specificity:Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.,

Specifications

Size	50μL/100μL
Target	Centriolin
Reactivity	Human, Mouse
Applications	IHC, IF, ELISA
MW(Calculated)	113kD
MW(Observed)
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human CEP110. AA range:850-900
Specificity	Centriolin Polyclonal Antibody detects endogenous levels of Centriolin protein.
Gene Name	CCP110
Protein Name	Centriolar coiled-coil protein of 110 kDa
Other Name	CCP110; / CEP110; / CP110; / KIAA0419; / Centriolar coiled-coil protein of 110 kDa; / Centrosomal protein of 110 kDa; / CP110; / Cep110
Species	Human
Gene ID	9738
Uniprot	O43303,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q7TSH4
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, cilium basal body . Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by KIF24 (PubMed:21620453). Removed from centrioles by TTBK2, leading to initiation of ciliogenesis and localizes only to the daughter centriole in ciliated cells. In cytotoxic T lymphocytes remains associated with the mother centriole during docking of the centrosome at the immunological synapse upon target contact (By similarity). Recruited at the distal end of the mother centriole by MPHOSPH9 (PubMed:30375385). .
Tissue Expression	Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.
Signaling_pathway
Research Areas
Function	Function:Necessary for centrosome duplication. Collaborates with CEP97, being involved in the suppression of a cilia assembly program. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2.,induction:Up-regulated during the transition from G1 to S phase of the cell cycle. The highest levels are observed in S phase, after which the levels decrease markedly.,PTM:Phosphorylated by CDKs.,subunit:Interacts with CALM1, CETN2 and CEP97.,tissue specificity:Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.,