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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/DD1 Polyclonal Antibody
SKU: WP11966 Categories: ,

DD1 Polyclonal Antibody

Ucallm_WP11966-50

Price range: $268.00 through $328.00

SKU: WP11966-100
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Product details

Background:

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetDD1
ReactivityHuman
ApplicationsIHC, IF, ELISA
MW(Calculated)
MW(Observed)37kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from DD1 . at AA range: 30-110
SpecificityDD1 Polyclonal Antibody detects endogenous levels of DD1 protein.
Gene NameAKR1C1
Protein NameAldo-keto reductase family 1 member C1
Other NameAKR1C1; / DDH; / DDH1; / Aldo-keto reductase family 1 member C1; / 20-alpha-hydroxysteroid dehydrogenase; / 20-alpha-HSD; / Chlordecone reductase homolog HAKRC; / Dihydrodiol dehydrogenase 1/2; / DD1/DD2; / High-affinity hepatic bile acid-binding protein; / HB
SpeciesHuman
Gene ID1645
UniprotQ04828
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCytoplasm, cytosol .
Tissue ExpressionExpressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary gland and brain.
Signaling_pathway
Research Areas>>Steroid hormone biosynthesis; / >>Metabolism of xenobiotics by cytochrome P450; / >>Metabolic pathways; / >>Chemical carcinogenesis - reactive oxygen species
FunctionCatalytic activity:17-alpha,20-alpha-dihydroxypregn-4-en-3-one + NAD(P)(+) = 17-alpha-hydroxyprogesterone + NAD(P)H.,Catalytic activity:Indan-1-ol + NAD(P)(+) = indanone + NAD(P)H.,Catalytic activity:Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH.,enzyme regulation:Inhibited by hexestrol with an IC(50) of 9.5 uM, 1,10-phenanthroline with an IC(50) of 55 uM, 1,7-phenanthroline with an IC(50) of 72 uM, flufenamic acid with an IC(50) of 6.0 uM, indomethacin with an IC(50) of 140 uM, ibuprofen with an IC(50) of 950 uM, lithocholic acid with an IC(50) of 25 uM, ursodeoxycholic acid with an IC(50) of 340 uM and chenodeoxycholic acid with an IC(50) of 570 uM.,Function:Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.,similarity:Belongs to the aldo/keto reductase family.,subunit:Monomer.,tissue specificity:Expressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary gland and brain.,
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