Name: DD2 Polyclonal Antibody
SKU: WP11967
Price: 268 USD
Availability: InStock

DD2 Polyclonal Antibody

Ucallm_WP11967-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP11967-100

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Product details

Background:

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],

Specifications

Size	50μL/100μL
Target	DD2
Reactivity	Human
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	37kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human AKR1C2. AA range:21-70
Specificity	DD2 Polyclonal Antibody detects endogenous levels of DD2 protein.
Gene Name	AKR1C2
Protein Name	Aldo-keto reductase family 1 member C2
Other Name	AKR1C2; / DDH2; / Aldo-keto reductase family 1 member C2; / 3-alpha-HSD3; / Chlordecone reductase homolog HAKRD; / Dihydrodiol dehydrogenase 2; / DD-2; / DD2; / Dihydrodiol dehydrogenase/bile acid-binding protein; / DD/BABP; / Trans-1; / 2-dihydrobenzene-1,2-diol
Species	Human
Gene ID	1646
Uniprot	P52895
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasm, cytosol .
Tissue Expression	Expressed in fetal testes. Expressed in fetal and adult adrenal glands.
Signaling_pathway
Research Areas	>>Steroid hormone biosynthesis; / >>Chemical carcinogenesis - DNA adducts; / >>Chemical carcinogenesis - reactive oxygen species
Function	Catalytic activity:Androsterone + NAD(P)(+) = 5-alpha-androstane-3,17-dione + NAD(P)H.,Catalytic activity:Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH.,enzyme regulation:Inhibited by hexestrol with an IC(50) of 2.8 uM, 1,10-phenanthroline with an IC(50) of 2100 uM, 1,7-phenanthroline with an IC(50) of 1500 uM, flufenamic acid with an IC(50) of 0.9 uM, indomethacin with an IC(50) of 75 uM, ibuprofen with an IC(50) of 6.9 uM, lithocholic acid with an IC(50) of 0.07 uM, ursodeoxycholic acid with an IC(50) of 0.08 uM and chenodeoxycholic acid with an IC(50) of 0.13 uM.,Function:Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability.,similarity:Belongs to the aldo/keto reductase family.,