Name: EP4 Polyclonal Antibody
SKU: WP12195
Price: 268 USD
Availability: InStock

EP4 Polyclonal Antibody

Ucallm_WP12195-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP12195-100

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Product details

Background:

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	EP4
Reactivity	Human, Mouse, Rat
Applications	WB, IF, ELISA
MW(Calculated)
MW(Observed)	55kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human PE2R4. AA range:321-370
Specificity	EP4 Polyclonal Antibody detects endogenous levels of EP4 protein.
Gene Name	PTGER4
Protein Name	Prostaglandin E2 receptor EP4 subtype
Other Name	PTGER4; / PTGER2; / Prostaglandin E2 receptor EP4 subtype; / PGE receptor EP4 subtype; / PGE2 receptor EP4 subtype; / Prostanoid EP4 receptor
Species	Human
Gene ID	5734
Uniprot	P35408,
Species.1	Mouse
Gene ID.1
Uniprot.1	P32240
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cell membrane; Multi-pass membrane protein.
Tissue Expression	High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle.
Signaling_pathway	Organismal Systems >> Sensory system >> Inflammatory mediator regulation of TRP channels;Human Diseases >> Cancer: overview >> Pathways in cancer
Research Areas	>>Neuroactive ligand-receptor interaction; / >>Inflammatory mediator regulation of TRP channels; / >>Renin secretion; / >>Human cytomegalovirus infection; / >>Human papillomavirus infection; / >>Pathways in cancer
Function	Caution:Was originally designated as the EP2 subtype.,Function:Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with FEM1A.,tissue specificity:High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle.,