Price range: $268.00 through $328.00
Background:
This gene encodes a protein that binds inositol 1, 3, 4, 5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],
| Target | GAP1-InsP4 BP |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 95kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human RASA3. AA range:247-296 |
| Sequence | |
| Specificity | GAP1-InsP4 BP Polyclonal Antibody detects endogenous levels of GAP1-InsP4 BP protein. |
| Gene Name | RASA3 |
| Protein Name | Ras GTPase-activating protein 3 |
| Other Name | RASA3; / Ras GTPase-activating protein 3; / GAP1; / IP4BP; / Ins P4-binding protein |
| Species | Human |
| Gene ID-1 | 22821 |
| Uniprot | Q14644, |
| Species.1 | Mouse |
| Gene ID-2 | 19414 |
| Uniprot.1 | Q60790, |
| Species.2 | Rat |
| Gene ID-3 | 29372 |
| Uniprot.2 | Q9QYJ2 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016], |
| Cellular Localization | Cell membrane. |
| Tissue Expression | Blood,Brain,Peripheral blood,Platelet,Testis, |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Ras signaling pathway |
| Research Areas | >>Ras signaling pathway |
| Function | Function:Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.,similarity:Contains 1 Btk-type zinc finger.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-GAP domain.,similarity:Contains 2 C2 domains., |
| RRID |
