Price range: $268.00 through $328.00
Background:
Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | GBP1 |
| Reactivity | Human, Mouse |
| Applications | WB, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 68kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GBP1. AA range:71-120 |
| Specificity | GBP1 Polyclonal Antibody detects endogenous levels of GBP1 protein. |
| Gene Name | GBP1 |
| Protein Name | Interferon-induced guanylate-binding protein 1 |
| Other Name | GBP1; / Interferon-induced guanylate-binding protein 1; / GTP-binding protein 1; / GBP-1; / HuGBP-1; / Guanine nucleotide-binding protein 1 |
| Species | Human |
| Gene ID | 2633 |
| Uniprot | P32455, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q01514 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Cell membrane . Secreted . Cytoplasmic vesicle . Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of IFNG induction. Golgi membrane localization requires isoprenylation and the presence of another IFNG-induced factor. |
| Tissue Expression | Placenta,Spleen,Uterus, |
| Signaling_pathway | Organismal Systems >> Immune system >> NOD-like receptor signaling pathway |
| Research Areas | >>NOD-like receptor signaling pathway |
| Function | Function:Binds GTP, GDP and GMP.,induction:By interferon gamma during macrophage activation.,similarity:Belongs to the GBP family., |
