Price range: $268.00 through $328.00
Background:
cell adhesion molecule 3(CADM3) Homo sapiens IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectins (see PVRL3; MIM 607147) (Kakunaga et al., 2005 [PubMed 15741237]).[supplied by OMIM, Mar 2008],
| Size | 50μL/100μL |
| Target | IGSF4B |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 43kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CADM3. AA range:141-190 |
| Specificity | IGSF4B Polyclonal Antibody detects endogenous levels of IGSF4B protein. |
| Gene Name | CADM3 |
| Protein Name | Cell adhesion molecule 3 |
| Other Name | CADM3; / IGSF4B; / NECL1; / SYNCAM3; / TSLL1; / Cell adhesion molecule 3; / Brain immunoglobulin receptor; / Immunoglobulin superfamily member 4B; / IgSF4B; / Nectin-like protein 1; / NECL-1; / Synaptic cell adhesion molecule 3; / SynCAM3; / TSLC1-like protein 1; / TS |
| Species | Human |
| Gene ID | 57863 |
| Uniprot | Q8N126, |
| Species.1 | Mouse |
| Gene ID.1 | 94332 |
| Uniprot.1 | Q99N28, |
| Species.2 | Rat |
| Gene ID.2 | 360882 |
| Uniprot.2 | Q1WIM3 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . Cell junction . |
| Tissue Expression | Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum. |
| Signaling_pathway | Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules |
| Research Areas | >>Cell adhesion molecules |
| Function | Domain:The cytoplasmic region mediates interaction with EPB41L1, DLG3, MPP6 and CASK.,Function:Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions.,induction:Markedly in glioma cell lines and prostate cancer cell lines.,similarity:Belongs to the nectin family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Localized at the cell-cell attached sites of the plasma membrane.,subunit:Homodimer. Can form trans-heterodimers with PVRL3/nectin-3. Interacts with EPB41L1, DLG3, MPP6 and CASK.,tissue specificity:Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum., |
