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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/IL-13Rα1 Polyclonal Antibody
SKU: WP12808 Categories: ,

IL-13Rα1 Polyclonal Antibody

Ucallm_WP12808-50

Price range: $268.00 through $328.00

SKU: WP12808-100
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Product details

Background:

The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetIL-13Rα1
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)49kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human IL-13R/CD213 alpha1. AA range:371-420
SpecificityIL-13Rα1 Polyclonal Antibody detects endogenous levels of IL-13Rα1 protein.
Gene NameIL13RA1
Protein NameInterleukin-13 receptor subunit alpha-1
Other NameIL13RA1; / IL13R; / IL13RA; / Interleukin-13 receptor subunit alpha-1; / IL-13 receptor subunit alpha-1; / IL-13R subunit alpha-1; / IL-13R-alpha-1; / IL-13RA1; / Cancer/testis antigen 19; / CT19; / CD antigen CD213a1
SpeciesHuman
Gene ID3597
UniprotP78552,
Species.1Mouse
Gene ID.116164
Uniprot.1O09030
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationMembrane; Single-pass type I membrane protein.
Tissue ExpressionUbiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.
Signaling_pathwayHuman Diseases >> Cancer: overview >> Pathways in cancer;Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Research Areas>>Cytokine-cytokine receptor interaction; / >>JAK-STAT signaling pathway; / >>Pathways in cancer
FunctionDomain:The box 1 motif is required for JAK interaction and/or activation.,Domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,Function:Binds IL13 with a low affinity. Together with IL4R-alpha can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for IL4 signaling, but cannot replace the function of gamma C in allowing enhanced IL2 binding activity.,similarity:Belongs to the type I cytokine receptor family. Type 5 subfamily.,subunit:Interleukin 13 receptor is a complex of IL4R, IL13RA1, and possibly other components. Interacts with TRAF3IP1.,tissue specificity:Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.,
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