Price range: $268.00 through $328.00
Background:
developmental stage:Expressed in fetal brain., function:May be involved in fat metabolism., similarity:Belongs to the CD225 family., tissue specificity:Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus.,
| Size | 50μL/100μL |
| Target | LOST1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IF, ELISA, IHC |
| MW(Calculated) | |
| MW(Observed) | 22kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300; IF 1:200-1:1000; ELISA 1:2000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TUSC5. AA range:1-50 |
| Specificity | LOST1 Polyclonal Antibody detects endogenous levels of LOST1 protein. |
| Gene Name | TUSC5 |
| Protein Name | Tumor suppressor candidate 5 |
| Other Name | TUSC5; / IFITMD3; / LOST1; / Tumor suppressor candidate 5; / Dispanin subfamily B member 1; / DSPB1; / Interferon-induced transmembrane domain-containing protein D3; / Protein located at seventeen-p-thirteen point three 1 |
| Species | Human |
| Gene ID | 286753 |
| Uniprot | Q8IXB3, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8C838 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass membrane protein . Endomembrane system; Single-pass membrane protein . Cytoplasm, perinuclear region . Shifts from low-density microsome vesicles to the cell membrane upon insulin stimulation. . |
| Tissue Expression | Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus (PubMed:12660825). Expressed in adipose tissue (PubMed:26629404). |
| Signaling_pathway | |
| Research Areas | |
| Function | developmental stage:Expressed in fetal brain.,Function:May be involved in fat metabolism.,similarity:Belongs to the CD225 family.,tissue specificity:Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus., |
