SKU: WP14294 Categories: ,

Ribosomal Protein L11 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP14294-100
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Product details

Background:

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010],

Specifications

Size50μL/100μL
TargetRibosomal Protein L11
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA, IHC
MW(Calculated)
MW(Observed)20kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from Ribosomal Protein L11 . at AA range: 100-180
SpecificityRibosomal Protein L11 Polyclonal Antibody detects endogenous levels of Ribosomal Protein L11 protein.
Gene NameRPL11
Protein Name60S ribosomal protein L11
Other NameRPL11; / 60S ribosomal protein L11; / CLL-associated antigen KW-12
SpeciesHuman
Gene ID6135
UniprotP62913,
Species.1Mouse
Gene ID.167025
Uniprot.1Q9CXW4,
Species.2Rat
Gene ID.2
Uniprot.2P62914
Cellular LocalizationNucleus, nucleolus . Cytoplasm .
Tissue ExpressionAmygdala,Cervix carcinoma,Tonsil,
Signaling_pathway
Research Areas>>Ribosome; / >>Coronavirus disease - COVID-19
FunctionDisease:Defects in RPL11 are the cause of Diamond-Blackfan anemia type 7 (DBA7) [MIM:612562]. DBA7 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.,Function:Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits.,similarity:Belongs to the ribosomal protein L5P family.,
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