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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/SIRT3 Polyclonal Antibody
SKU: WP14489 Categories: ,

SIRT3 Polyclonal Antibody

Ucallm_WP14489-50

Price range: $268.00 through $328.00

SKU: WP14489-100
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Product details

Background:

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008],

Specifications

TargetSIRT3
ReactivityHuman, Mouse
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)45kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Modification
Recommended Dilution RatioWB 1:500-1:2000; ELISA 1:5000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human SIRT3. AA range:350-399
Sequence
SpecificitySIRT3 Polyclonal Antibody detects endogenous levels of SIRT3 protein.
Gene NameSIRT3
Protein NameNAD-dependent protein deacetylase sirtuin-3 mitochondrial
Other NameSIRT3; / SIR2L3; / NAD-dependent protein deacetylase sirtuin-3; / mitochondrial; / hSIRT3; / Regulatory protein SIR2 homolog 3; / SIR2-like protein 3
SpeciesHuman
Gene ID-123410
UniprotQ9NTG7,
Species.1Mouse
Gene ID-2
Uniprot.1Q8R104
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
BackgroundThis gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008],
Cellular LocalizationMitochondrion matrix .
Tissue ExpressionWidely expressed.
Signaling_pathwayHuman Diseases >> Cancer: overview >> Central carbon metabolism in cancer
Research Areas>>Nicotinate and nicotinamide metabolism; / >>Metabolic pathways; / >>Central carbon metabolism in cancer
FunctionCatalytic activity:NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.,cofactor:Binds 1 zinc ion per subunit.,Function:NAD-dependent deacetylase. Despite some ability to deacetylate histones in vitro, it is unlikely in vivo.,PTM:Processed by mitochondrial processing peptidase (MPP) to give a 28 kDa product. Such processing is probably essential for its enzymatic activity.,similarity:Belongs to the sirtuin family.,similarity:Contains 1 deacetylase sirtuin-type domain.,tissue specificity:Widely expressed.,
RRID
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