Price range: $268.00 through $328.00
Background:
This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],
| Size | 50μL/100μL |
| Target | TSSK 4 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 40kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TSSK4. AA range:211-260 |
| Specificity | TSSK 4 Polyclonal Antibody detects endogenous levels of TSSK 4 protein. |
| Gene Name | TSSK4 |
| Protein Name | Testis-specific serine/threonine-protein kinase 4 |
| Other Name | TSSK4; / C14orf20; / STK22E; / TSSK5; / Testis-specific serine/threonine-protein kinase 4; / TSK-4; / TSSK-4; / Testis-specific kinase 4; / Serine/threonine-protein kinase 22E |
| Species | Human |
| Gene ID | 283629 |
| Uniprot | Q6SA08, |
| Species.1 | Mouse |
| Gene ID.1 | 71099 |
| Uniprot.1 | Q9D411 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasmic vesicle, secretory vesicle, acrosome . Cell projection, cilium, flagellum . In spermatozoa, present in the sperm head and in the flagellum. . |
| Tissue Expression | Expressed only in the testis. |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-197, potentially by autophosphorylation.,Function:May be involved in a signaling pathway during male germ cell development or mature sperm function (By similarity). Phosphorylates CREB1 on Ser-133 and stimulates downstream signaling.,PTM:Autophosphorylated (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed only in the testis., |
