Price range: $268.00 through $328.00
Background:
This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011],
| Size | 50μL/100μL |
| Target | TULA |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 75kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:5000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human UBASH3A. AA range:311-360 |
| Specificity | TULA Polyclonal Antibody detects endogenous levels of TULA protein. |
| Gene Name | UBASH3A |
| Protein Name | Ubiquitin-associated and SH3 domain-containing protein A |
| Other Name | UBASH3A; / STS2; / Ubiquitin-associated and SH3 domain-containing protein A; / Cbl-interacting protein 4; / CLIP4; / Suppressor of T-cell receptor signaling 2; / STS-2; / T-cell ubiquitin ligand 1; / TULA-1 |
| Species | Human |
| Gene ID | 53347 |
| Uniprot | P57075, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q3V3E1 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm. Nucleus. |
| Tissue Expression | Highest expression of UBASH3A in tissues belonging to the immune system, including spleen, peripheral blood leukocytes, thymus and bone marrow. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface.,similarity:Contains 1 SH3 domain.,similarity:Contains 1 UBA domain.,subunit:Homodimer or homooligomer. Interacts with CBL. Part of a complex containing CBL and activated EGFR. Interacts with ubiquitin and with mono-ubiquitinated proteins.,tissue specificity:Highest expression of UBASH3A in tissues belonging to the immune system, including spleen, peripheral blood leukocytes, thymus and bone marrow., |
