Name: ALDH3A1 Polyclonal Antibody
SKU: WP15124
Price: 268 USD
Availability: InStock

ALDH3A1 Polyclonal Antibody

Ucallm_WP15124-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP15124-100

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Product details

Background:

Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008],

Specifications

Size	50μL/100μL
Target	ALDH3A1
Reactivity	Human, Rat
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	50kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human ALDH3A1. AA range:236-285
Specificity	ALDH3A1 Polyclonal Antibody detects endogenous levels of ALDH3A1 protein.
Gene Name	ALDH3A1
Protein Name	Aldehyde dehydrogenase dimeric NADP-preferring
Other Name	ALDH3A1; / ALDH3; / Aldehyde dehydrogenase, dimeric NADP-preferring; / ALDHIII; / Aldehyde dehydrogenase 3; / Aldehyde dehydrogenase family 3 member A1
Species	Human
Gene ID	218
Uniprot	P30838,
Species.1	Mouse
Gene ID.1
Uniprot.1	P47739,
Species.2	Rat
Gene ID.2	25375
Uniprot.2	P11883
Cellular Localization	Cytoplasm .
Tissue Expression	High levels in stomach, esophagus and lung; low level in the liver and kidney.
Signaling_pathway
Research Areas	>>Glycolysis / Gluconeogenesis; / >>Histidine metabolism; / >>Tyrosine metabolism; / >>Phenylalanine metabolism; / >>beta-Alanine metabolism; / >>Metabolism of xenobiotics by cytochrome P450; / >>Drug metabolism - cytochrome P450; / >>Metabolic pathways
Function	Catalytic activity:An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H.,Function:ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes.,similarity:Belongs to the aldehyde dehydrogenase family.,subunit:Homodimer.,tissue specificity:High levels in stomach, esophagus and lung; low level in the liver and kidney.,