Name: FGF-5 Polyclonal Antibody
SKU: WP15267
Price: 268 USD
Availability: InStock

FGF-5 Polyclonal Antibody

Ucallm_WP15267-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP15267-100

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Product details

Background:

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	FGF-5
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	30kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from the C-terminal region of human FGF5. AA range:211-260
Specificity	FGF-5 Polyclonal Antibody detects endogenous levels of FGF-5 protein.
Gene Name	FGF5
Protein Name	Fibroblast growth factor 5
Other Name	FGF5; / Fibroblast growth factor 5; / FGF-5; / Heparin-binding growth factor 5; / HBGF-5; / Smag-82
Species	Human
Gene ID	2250
Uniprot	P12034,
Species.1	Mouse
Gene ID.1
Uniprot.1	P15656
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Secreted .
Tissue Expression	Expressed in neonatal brain.
Signaling_pathway	Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Gastric cancer;Human Diseases >> Cancer: specific types >> Melanoma;Human Diseases >> Cancer: specific types >> Breast cancer;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> Ras signaling pathway;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Research Areas	>>MAPK signaling pathway; / >>Ras signaling pathway; / >>Rap1 signaling pathway; / >>Calcium signaling pathway; / >>PI3K-Akt signaling pathway; / >>Regulation of actin cytoskeleton; / >>Pathways in cancer; / >>Chemical carcinogenesis - receptor activation; / >>Melanoma; / >>Breast cancer; / >>Gastric cancer
Function	developmental stage:Can transform NIH 3T3 cells.,Function:Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase.,similarity:Belongs to the heparin-binding growth factors family.,tissue specificity:Expressed in neonatal brain.,