SKU: WP15287 Categories: ,

FOXP1 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP15287-100
Enter the quantity you would like, or drag the panel to find the quantity and price that best for you
Bulk QuoteAuthorize OEM & ODM

Product details

Background:

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetFOXP1
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)75kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from the C-terminal region of human FOXP1. AA range:628-677
SpecificityFOXP1 Polyclonal Antibody detects endogenous levels of FOXP1 protein.
Gene NameFOXP1
Protein NameForkhead box protein P1
Other NameFOXP1; / HSPC215; / Forkhead box protein P1
SpeciesHuman
Gene ID27086
UniprotQ9H334,
Species.1Mouse
Gene ID.1108655
Uniprot.1P58462,
Species.2Rat
Gene ID.2297480
Uniprot.2Q498D1
Cellular LocalizationNucleus . Not found in the nucleolus. .
Tissue ExpressionIsoform 8 is specifically expressed in embryonic stem cells.
Signaling_pathwayHuman Diseases >> Cancer: overview >> MicroRNAs in cancer
Research Areas>>MicroRNAs in cancer
FunctionAlternative products:Additional isoforms seem to exist,Disease:A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. Translocation t(9; 3)(p13; p14.1) with PAX5.,Domain:The leucine-zipper is required for dimerization and transcriptional repression.,Function:Transcriptional repressor that plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B cell development.,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 1 fork-head DNA-binding domain.,subunit:Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1.,
Please login to post questions
Back to Top
Product has been added to your cart