Name: ECA39 Polyclonal Antibody
SKU: WP15474
Price: 268 USD
Availability: InStock

ECA39 Polyclonal Antibody

Ucallm_WP15474-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP15474-100

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Product details

Background:

branched chain amino acid transaminase 1(BCAT1) Homo sapiens This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2010],

Specifications

Size	50μL/100μL
Target	ECA39
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	43kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from the Internal region of human BCAT1. AA range:231-280
Specificity	ECA39 Polyclonal Antibody detects endogenous levels of ECA39 protein.
Gene Name	BCAT1
Protein Name	Branched-chain-amino-acid aminotransferase, cytosolic
Other Name	BCAT1; / BCT1; / ECA39; / Branched-chain-amino-acid aminotransferase, cytosolic; / BCAT; / c; / Protein ECA39
Species	Human
Gene ID	586
Uniprot	P54687,
Species.1	Mouse
Gene ID.1	12035
Uniprot.1	P24288,
Species.2	Rat
Gene ID.2	29592
Uniprot.2	P54690
Cellular Localization	Cytoplasm.
Tissue Expression	During embryogenesis, expressed in the brain and kidney. Overexpressed in MYC-induced tumors such as Burkitt's lymphoma.
Signaling_pathway
Research Areas	>>Cysteine and methionine metabolism; / >>Valine, leucine and isoleucine degradation; / >>Valine, leucine and isoleucine biosynthesis; / >>Pantothenate and CoA biosynthesis; / >>Metabolic pathways; / >>2-Oxocarboxylic acid metabolism; / >>Biosynthesis of amino acids; / >>Biosynthesis of cofactors
Function	Catalytic activity:2-oxoglutaric acid + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid.,Catalytic activity:2-oxoglutaric acid + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamic acid.,Catalytic activity:L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.,cofactor:Pyridoxal phosphate.,Function:Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.,similarity:Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.,subunit:Homodimer.,tissue specificity:During embryogenesis, expressed in the brain and kidney. Overexpressed in C-myc induced tumors such as Burkitt's lymphoma.,