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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/EP1 Polyclonal Antibody
SKU: WP15478 Categories: ,

EP1 Polyclonal Antibody

Ucallm_WP15478-50

Price range: $268.00 through $328.00

SKU: WP15478-100
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Product details

Background:

The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetEP1
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)44kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human PTGER1. AA range:191-240
SpecificityEP1 Polyclonal Antibody detects endogenous levels of EP1 protein.
Gene NamePTGER1
Protein NameProstaglandin E2 receptor EP1 subtype
Other NamePTGER1; / Prostaglandin E2 receptor EP1 subtype; / PGE receptor EP1 subtype; / PGE2 receptor EP1 subtype; / Prostanoid EP1 receptor
SpeciesHuman
Gene ID5731
UniprotP34995,
Species.1Mouse
Gene ID.1
Uniprot.1P35375
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCell membrane; Multi-pass membrane protein.
Tissue ExpressionAbundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart.
Signaling_pathwayHuman Diseases >> Cancer: overview >> Pathways in cancer;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway
Research Areas>>Calcium signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>Human cytomegalovirus infection; / >>Pathways in cancer
FunctionFunction:Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.,PTM:Phosphorylated .,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart.,
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