Price range: $268.00 through $328.00
Background:
This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may play a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | TTYH2 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 59kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TTYH2 AA range: 319-369 |
| Specificity | This antibody detects endogenous levels of TTYH2 at Human/Mouse |
| Gene Name | TTYH2 C17orf29 |
| Protein Name | TTYH2 |
| Other Name | |
| Species | Human |
| Gene ID | 94015 |
| Uniprot | Q9BSA4, |
| Species.1 | Mouse |
| Gene ID.1 | 117160 |
| Uniprot.1 | Q3TH73 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . |
| Tissue Expression | Expressed at higher level in brain and testis and at lower levels in heart, ovary, spleen and peripheral blood leukocytes. Up-regulated in 13 of 16 renal cell carcinoma samples examined. Up-regulated in colon carcinoma. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation.,similarity:Belongs to the tweety family.,tissue specificity:Expressed at higher level in brain and testis and at lower levels in heart, ovary, spleen and peripheral blood leukocytes. Up-regulated in 13 of 16 renal cell carcinoma samples examined. Up-regulated in colon carcinoma., |
