β II tubulin Monoclonal Antibody [Mix]
Ucallm_WM1060-50
Price range: $268.00 through $328.00
Product details
Background:
Microtubules, key participants in processes such as mitosis and intracellular transport, are composed of heterodimers of alpha- and beta-tubulins. The protein encoded by this gene is a beta-tubulin. Defects in this gene are associated with complex cortical dysplasia with other brain malformations-5. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2015],
Specifications
| Size | 50μL/100μL |
| Target | Tubulin β II |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, IP |
| MW(Calculated) | |
| MW(Observed) | 50kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:50000-100000; IP 1:200; IHC 1:50-300; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 2G8 |
| Immunogen | Synthetic Peptide of β II tubulin |
| Specificity | The antibody detects endogenous β II tubulin protein. |
| Gene Name | TUBB2A TUBB2 |
| Protein Name | Tubulin beta-2A chain |
| Other Name | Tubulin beta-2A chain |
| Species | Human |
| Gene ID | 7280 |
| Uniprot | Q13885, |
| Species.1 | Mouse |
| Gene ID.1 | 22151 |
| Uniprot.1 | Q7TMM9, |
| Species.2 | Rat |
| Gene ID.2 | 498736 |
| Uniprot.2 | P85108 |
| Cellular Localization | Cytoplasm, cytoskeleton . |
| Tissue Expression | High expression in brain, where it represents 30% of all beta-tubulins. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Phagosome;Cellular Processes >> Cellular community - eukaryotes >> Gap junction;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Parkinson disease;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Huntington disease;Human Diseases >> Neurodegenerative disease >> Prion disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases |
| Research Areas | >>Phagosome; / >>Gap junction; / >>Alzheimer disease; / >>Parkinson disease; / >>Amyotrophic lateral sclerosis; / >>Huntington disease; / >>Prion disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Pathogenic Escherichia coli infection; / >>Salmonella infection |
| Function | Function:Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.,similarity:Belongs to the tubulin family.,subunit:Dimer of alpha and beta chains., |
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