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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/17β-HSD4 Polyclonal Antibody
SKU: WP15430 Categories: ,

17β-HSD4 Polyclonal Antibody

Ucallm_WP15430-50

Price range: $268.00 through $328.00

SKU: WP15430-100
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Product details

Background:

hydroxysteroid 17-beta dehydrogenase 4(HSD17B4) Homo sapiens The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014],

Specifications

Size50μL/100μL
Target17β-HSD4
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)80kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from the N-terminal region of human HSD17B4. AA range:41-90
Specificity17β-HSD4 Polyclonal Antibody detects endogenous levels of 17β-HSD4 protein.
Gene NameHSD17B4
Protein NamePeroxisomal multifunctional enzyme type 2
Other NameHSD17B4; / EDH17B4; / Peroxisomal multifunctional enzyme type 2; / MFE-2; / 17-beta-hydroxysteroid dehydrogenase 4; / 17-beta-HSD 4; / D-bifunctional protein; / DBP; / Multifunctional protein 2; / MPF-2
SpeciesHuman
Gene ID3295
UniprotP51659,
Species.1Mouse
Gene ID.115488
Uniprot.1P51660,
Species.2Rat
Gene ID.279244
Uniprot.2P97852
Cellular LocalizationPeroxisome .
Tissue ExpressionPresent in many tissues with highest concentrations in liver, heart, prostate and testis.
Signaling_pathwayCellular Processes >> Transport and catabolism >> Peroxisome
Research Areas>>Primary bile acid biosynthesis; / >>Biosynthesis of unsaturated fatty acids; / >>Metabolic pathways; / >>Fatty acid metabolism; / >>Peroxisome
FunctionCatalytic activity:(24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestanoyl-CoA = (24E)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA + H(2)O.,Catalytic activity:(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.,Disease:Defects in HSD17B4 are a cause of D-bifunctional protein deficiency (DBPD) [MIM:261515]. DBPD is a disorder of peroxisomal fatty acid beta-oxidation.,Function:Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids.,pathway:Lipid metabolism; fatty acid beta-oxidation.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,similarity:Contains 1 SCP2 domain.,tissue specificity:Present in many tissues with highest concentrations in liver, heart, prostate and testis.,
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