3HAO Polyclonal Antibody
Ucallm_WP0787-50
Price range: $268.00 through $328.00
Product details
Background:
3-Hydroxyanthranilate 3, 4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | 3HAO |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 31kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 30-110 |
| Specificity | 3HAO Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | HAAO |
| Protein Name | 3-hydroxyanthranilate 3,4-dioxygenase (3-hydroxyanthranilate oxygenase) (3-HAO) (3-hydroxyanthranilic acid dioxygenase) (HAD) |
| Other Name | |
| Species | Human |
| Gene ID | 23498 |
| Uniprot | P46952, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q78JT3, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P46953 |
| Cellular Localization | Cytoplasm, cytosol . |
| Tissue Expression | Brain,Hippocampus,Placenta, |
| Signaling_pathway | |
| Research Areas | >>Tryptophan metabolism; / >>Metabolic pathways; / >>Biosynthesis of cofactors |
| Function | Catalytic activity:3-hydroxyanthranilate + O(2) = 2-amino-3-carboxymuconate semialdehyde.,cofactor:Fe(2+) ion.,Function:Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.,pathway:Cofactor biosynthesis; NAD(+) biosynthesis; pyridine-2,3-dicarboxylate from L-kynurenine: step 3/3.,similarity:Belongs to the 3-HAO family.,subunit:Monomer., |
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