Product details
Background:
53BP1 (Phospho Thr543) rabbit pAb
Ucallm_WP10282-50
Price range: $288.00 through $368.00
Specifications
| Target | 53BP1 |
| Reactivity | Human, Rat, Mouse |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 213kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate | |
| Modification | Phospho |
| Recommended Dilution Ratio | WB 1:1000-2000 |
| Composition | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification Process | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Purity | |
| Storage Condition | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized phosho peptide around human 53BP1 (Thr543) |
| Sequence | |
| Specificity | This antibody detects endogenous levels of Human 53BP1 (phospho-Thr543) |
| Gene Name | TP53BP1 |
| Protein Name | 53BP1 (Thr543) |
| Alias | Tumor suppressor p53-binding protein 1;53BP1;p53-binding protein 1;p53BP1; |
| Organism-1 | Human |
| Gene ID-1 | 7158 |
| SwissProt-1 | Q12888 |
| Organism-2 | Mouse |
| Gene ID-2 | 27223 |
| SwissProt-2 | P70399 |
| Organism-3 | |
| Gene ID-3 | |
| SwissProt-3 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Cellular Localization | Nucleus . Chromosome . Chromosome, centromere, kinetochore . Localizes to the nucleus in absence of DNA damage (PubMed:28241136). Following DNA damage, recruited to sites of DNA damage, such as double stand breaks (DSBs): recognizes and binds histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23333306, PubMed:23760478, PubMed:24703952, PubMed:28241136, PubMed:17190600). Associated with kinetochores during mitosis (By similarity). . |
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