A Cyclase V/VI Polyclonal Antibody
Ucallm_WP10869-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the adenylyl cyclase family of proteins, which are required for the synthesis of cyclic AMP. All members of this family have an intracellular N-terminus, a tandem repeat of six transmembrane domains separated by a cytoplasmic loop, and a C-terminal cytoplasmic domain. The two cytoplasmic regions bind ATP and form the catalytic core of the protein. Adenylyl cyclases are important effectors of transmembrane signaling pathways and are regulated by the activity of G protein coupled receptor signaling. This protein belongs to a small subclass of adenylyl cyclase proteins that are functionally related and are inhibited by protein kinase A, calcium ions and nitric oxide. A mutation in this gene is associated with arthrogryposis multiplex congenita. [provided by RefSeq, May 2015],
Specifications
| Size | 50μL/100μL |
| Target | ADCY5 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 131kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ADCY5/6. AA range:931-980 |
| Specificity | A Cyclase V/VI Polyclonal Antibody detects endogenous levels of A Cyclase V/VI protein. |
| Gene Name | ADCY5/ADCY6 |
| Protein Name | Adenylate cyclase type 5/6 |
| Other Name | ADCY6; / KIAA0422; / Adenylate cyclase type 6; / ATP pyrophosphate-lyase 6; / Adenylate cyclase type VI; / Adenylyl cyclase 6; / Ca; / 2+; / -inhibitable adenylyl cyclase; / ADCY5; / Adenylate cyclase type 5; / ATP pyrophosphate-lyase 5; / Adenylate cyclase type V |
| Species | Human |
| Gene ID | 112;111 |
| Uniprot | O43306;O95622, |
| Species.1 | Mouse |
| Gene ID.1 | 11512;224129, |
| Uniprot.1 | |
| Species.2 | Rat |
| Gene ID.2 | 64532 |
| Uniprot.2 | Q03343;Q04400 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . Cell projection, cilium . Cell projection, stereocilium . |
| Tissue Expression | Detected in peripheral blood mononuclear leukocytes (at protein level) (PubMed:17916776). Detected in thyroid (PubMed:10978539). |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Gap junction;Organismal Systems >> Immune system >> Platelet activation;Organismal Systems >> Immune system >> Chemokine signaling pathway;Organismal Systems >> Endocrine system >> Insulin secretion;Organismal Systems >> Endocrine system >> GnRH signaling pathway;Organismal Systems >> Endocrine system >> Estrogen signaling pathway;Organismal Systems >> Endocrine system >> Oxytocin signaling pathway;Organismal Systems >> Endocrine system >> Relaxin signaling pathway;Organismal Systems >> Endocrine system >> Growth hormone synthesis, secretion and action;Organismal Systems >> Endocrine system >> Aldosterone synthesis and secretion;Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes;Organismal Systems >> Circulatory system >> Vascular smooth muscle contraction;Organismal Systems >> Nervous system >> Glutamatergic synapse;Organismal Systems >> Nervous system >> Cholinergic synapse;Organismal Systems >> Nervous system >> Dopaminergic synapse;Organismal Systems >> Sensory system >> Inflammatory mediator regulation of TRP channels;Organismal Systems >> Aging >> Longevity regulating pathway;Organismal Systems >> Aging >> Longevity regulating pathway - multiple species;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Neurodegenerative disease >> Parkinson disease;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway;Environmental Information Processing >> Signal transduction >> Apelin signaling pathway;Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway;Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway |
| Research Areas | >>Purine metabolism; / >>Metabolic pathways; / >>Endocrine resistance; / >>Rap1 signaling pathway; / >>cGMP-PKG signaling pathway; / >>cAMP signaling pathway; / >>Chemokine signaling pathway; / >>Phospholipase D signaling pathway; / >>Oocyte meiosis; / >>Longevity regulating pathway; / >>Longevity regulating pathway - multiple species; / >>Adrenergic signaling in cardiomyocytes; / >>Vascular smooth muscle contraction; / >>Apelin signaling pathway; / >>Gap junction; / >>Platelet activation; / >>Circadian entrainment; / >>Thermogenesis; / >>Retrograde endocannabinoid signaling; / >>Glutamatergic synapse; / >>Cholinergic synapse; / >>GABAergic synapse; / >>Taste transduction; / >>Inflammatory mediator regulation of TRP channels; / >>Insulin secretion; / >>GnRH signaling pathway; / >>Ovarian steroidogenesis; / >>Progesterone-mediated oocyte maturation; / >>Estrogen signaling pathway; / >>Melanogenesis; / >>Thyroid hormone synthesis; / >>Oxytocin signaling pathway; / >>Regulation of lipolysis in adipocytes; / >>Renin secretion; / >>Aldosterone synthesis and secretion; / >>Relaxin signaling pathway; / >>Cortisol synthesis and secretion; / >>Parathyroid hormone synthesis, secretion and action; / >>Cushing syndrome; / >>Growth hormone synthesis, secretion and action; / >>Endocrine and other factor-regulated calcium reabsorption; / >>Vasopressin-regulated water reabsorption; / >>Salivary secretion; / >>Gastric acid secretion; / >>Pancreatic secretion; / >>Bile secretion; / >>Morphine addiction; / >>Human cytomegalovirus infection; / >>Human T-cell leukemia virus 1 infection; / >>Pathways in cancer; / >>Chemical carcinogenesis - receptor activation; / >>Dilated cardiomyopathy |
| Function | Catalytic activity:ATP = 3',5'-cyclic AMP + diphosphate.,cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Inhibition by calcium in the submicromolar concentration range.,Function:Membrane-bound, calcium-inhibitable adenylyl cyclase.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 2 guanylate cyclase domains., |
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