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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/A1Up Polyclonal Antibody
SKU: WP10872 Categories: ,

A1Up Polyclonal Antibody

Ucallm_WP10872-50

Price range: $268.00 through $328.00

SKU: WP10872-100
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Product details

Background:

PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Contains 1 UBA domain., similarity:Contains 1 ubiquitin-like domain., subcellular location:May associate with the endoplasmic reticulum., subunit:Homodimer. Binds SCA1. Binds signal sequences of proteins that are targeted to the endoplasmic reticulum., tissue specificity:Highly expressed in pancreas, kidney, skeletal muscle, heart and throughout the brain, and at lower levels in placenta, lung and liver.,

Specifications

Size50μL/100μL
TargetA1Up
ReactivityHuman, Mouse
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)54kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human UBQLN4. AA range:201-250
SpecificityA1Up Polyclonal Antibody detects endogenous levels of A1Up protein.
Gene NameUBQLN4
Protein NameUbiquilin-4
Other NameUBQLN4; / C1orf6; / CIP75; / UBIN; / Ubiquilin-4; / Ataxin-1 interacting ubiquitin-like protein; / A1Up; / Ataxin-1 ubiquitin-like-interacting protein A1U; / Connexin43-interacting protein of 75 kDa; / CIP75
SpeciesHuman
Gene ID56893
UniprotQ9NRR5,
Species.1Mouse
Gene ID.194232
Uniprot.1Q99NB8
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationNucleus . Cytoplasm . Chromosome . Endoplasmic reticulum . Cytoplasm, perinuclear region . Cytoplasmic vesicle, autophagosome . Colocalizes with the proteasome, both in nucleus and cytoplasm (PubMed:15280365). Exported from the nucleus following interaction with DESI1/POST (PubMed:29666234). In response to DNA damage and phosphorylation at Ser-318 by ATM, localizes to the nucleus and is recruited to sites of DNA damage (PubMed:30612738). .
Tissue ExpressionHighly expressed in pancreas, kidney, skeletal muscle, heart and throughout the brain, and at lower levels in placenta, lung and liver.
Signaling_pathwayHuman Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Genetic Information Processing >> Folding, sorting and degradation >> Protein processing in endoplasmic reticulum
Research Areas>>Protein processing in endoplasmic reticulum; / >>Amyotrophic lateral sclerosis
FunctionPTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 UBA domain.,similarity:Contains 1 ubiquitin-like domain.,subcellular location:May associate with the endoplasmic reticulum.,subunit:Homodimer. Binds SCA1. Binds signal sequences of proteins that are targeted to the endoplasmic reticulum.,tissue specificity:Highly expressed in pancreas, kidney, skeletal muscle, heart and throughout the brain, and at lower levels in placenta, lung and liver.,
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