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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/A4GAT Polyclonal Antibody
SKU: WP1239 Categories: ,

A4GAT Polyclonal Antibody

Ucallm_WP1239-50

Price range: $268.00 through $328.00

SKU: WP1239-100
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Product details

Background:

alpha 1, 4-galactosyltransferase(A4GALT) Homo sapiens The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. This protein, a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015],

Specifications

Size50μL/100μL
TargetA4GAT
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)38kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein
SpecificityA4GAT Polyclonal Antibody detects endogenous levels of protein.
Gene NameA4GALT A14GALT A4GALT1
Protein NameLactosylceramide 4-alpha-galactosyltransferase (Alpha-1,4-N-acetylglucosaminyltransferase) (Alpha-1,4-galactosyltransferase) (Alpha4Gal-T1) (CD77 synthase) (Globotriaosylceramide synthase) (Gb3 synthase) (P1/Pk synthase) (UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase)
Other Name
SpeciesHuman
Gene ID53947
UniprotQ9NPC4,
Species.1Mouse
Gene ID.1
Uniprot.1Q67BJ4,
Species.2Rat
Gene ID.2
Uniprot.2Q9JI93
Cellular LocalizationGolgi apparatus membrane; Single-pass type II membrane protein .
Tissue ExpressionUbiquitous. Highly expressed in kidney, heart, spleen, liver, testis and placenta.
Signaling_pathway
Research Areas>>Glycosphingolipid biosynthesis - lacto and neolacto series; / >>Glycosphingolipid biosynthesis - globo and isoglobo series; / >>Metabolic pathways
FunctionCatalytic activity:UDP-galactose + beta-D-galactosyl-(1->4)-D-glucosyl-(11)-ceramide = UDP + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-D-glucosyl-(11)-ceramide.,Domain:The conserved DXD motif is involved in enzyme activity.,Function:Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins.,online information:GlycoGene database,online information:Lactosylceramide 4-alpha-galactosyltransferase,pathway:Protein modification; protein glycosylation.,polymorphism:Different combinations or absence of the P blood group system antigens define 5 different phenotypes: P1, P2, P1(k), P2(k), and p. Genetic variation in A4GALT determines the p phenotype, which is rare and does not express any antigens. It is also known as null phenotype; p individuals have antibodies against P, P1 and Pk antigens in their sera. These antibodies are clinically important because they can cause severe transfusion reactions and miscarriage.,similarity:Belongs to the glycosyltransferase 32 family.,tissue specificity:Ubiquitous. Highly expressed in kidney, heart, spleen, liver, testis and placenta.,
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