Product details
Background:
ABCA2 rabbit pAb
Ucallm_WP8305-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | ABCA2 |
| Reactivity | Human, Rat |
| Applications | WB |
| MW(Calculated) | 268kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ABCA2 |
| Specificity | This antibody detects endogenous levels of ABCA2 at Human,Rat |
| Gene Name | ABCA2 ABC2 KIAA1062 |
| Protein Name | ATP-binding cassette sub-family A member 2 (ATP-binding cassette transporter 2) (ATP-binding cassette 2) |
| Other Name | |
| Species | Human |
| Gene ID | 20 |
| Uniprot | Q9BZC7, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P41234, |
| Species.2 | Rat |
| Gene ID.2 | 79248 |
| Uniprot.2 | Q9ESR9 |
| Cellular Localization | Endosome membrane; Multi-pass membrane protein . Lysosome membrane; Multi-pass membrane protein . Forms discrete, punctate intracellular vesicles. . |
| Tissue Expression | [Isoform 3]: Highly expressed in the brain,peripheral blood leukocytes and ovary, whereas lower levels of expression is observed in kidney and liver.; [Isoform 4]: Weakly expressed in brain and highly in peripheral blood leukocytes. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Lysosome |
| Research Areas | |
| Function | Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes . In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP . May play a role in myelin formation (By similarity). |
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