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ABCD2 Polyclonal Antibody
Ucallm_WP0903-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe
Specifications
| Size | 50μL/100μL |
| Target | ABCD2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 81kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 310-390 |
| Specificity | ABCD2 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | ABCD2 ALD1 ALDL1 ALDR ALDRP |
| Protein Name | ATP-binding cassette sub-family D member 2 (Adrenoleukodystrophy-like 1) (Adrenoleukodystrophy-related protein) (hALDR) |
| Other Name | |
| Species | Human |
| Gene ID | 225 |
| Uniprot | Q9UBJ2, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q61285, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q9QY44 |
| Cellular Localization | Peroxisome membrane; Multi-pass membrane protein . |
| Tissue Expression | Predominantly expressed in brain and heart. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Peroxisome |
| Research Areas | >>ABC transporters; / >>Peroxisome |
| Function | Function:Probable transporter.,similarity:Belongs to the ABC transporter family. ALD subfamily.,similarity:Contains 1 ABC transmembrane type-1 domain.,similarity:Contains 1 ABC transporter domain.,subunit:Can form heterodimers with ABCD1/ALD and ABCD3/PMP70. Dimerization is necessary to form an active transporter. Interacts with PEX19.,tissue specificity:Predominantly expressed in brain and heart., |
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