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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/ACAD-9 Polyclonal Antibody
SKU: WP10905 Categories: ,

ACAD-9 Polyclonal Antibody

Ucallm_WP10905-50

Price range: $268.00 through $328.00

SKU: WP10905-100
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Product details

Background:

This gene encodes a member of the acyl-CoA dehydrogenase family. Members of this family of proteins localize to the mitochondria and catalyze the rate-limiting step in the beta-oxidation of fatty acyl-CoA. The encoded protein is specifically active toward palmitoyl-CoA and long-chain unsaturated substrates. Mutations in this gene cause acyl-CoA dehydrogenase family member type 9 deficiency. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010],

Specifications

Size50μL/100μL
TargetACAD-9
ReactivityHuman, Mouse, Rat
ApplicationsIHC, IF, ELISA
MW(Calculated)69kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from ACAD-9 . at AA range: 530-610
SpecificityACAD-9 Polyclonal Antibody detects endogenous levels of ACAD-9 protein.
Gene NameACAD9
Protein NameAcyl-CoA dehydrogenase family member 9 mitochondrial
Other NameACAD9; / Acyl-CoA dehydrogenase family member 9; / mitochondrial; / ACAD-9
SpeciesHuman
Gene ID28976
UniprotQ9H845,
Species.1Mouse
Gene ID.1229211
Uniprot.1Q8JZN5
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationMitochondrion inner membrane; Peripheral membrane protein; Matrix side . Essentially associated with membranes. .
Tissue ExpressionUbiquitously expressed in most normal human tissues and cancer cell lines with high level of expression in heart, skeletal muscles, brain, kidney and liver (PubMed:12359260). In the cerebellum uniquely expressed in the granular layer (at protein level) (PubMed:21237683).
Signaling_pathway
Research Areas
Functioncofactor:FAD.,Disease:Defects in ACAD9 are a cause of acyl-CoA dehydrogenase family member type 9 deficiency (ACAD9 deficiency) [MIM:611126]. ACAD9 deficiency patients present with episodic liver dysfunction during otherwise mild illnesses or cardiomyopathy, along with chronic neurologic dysfunction.,Function:Has a dehydrogenase activity on palmitoyl-CoA (C16:0) and stearoyl-CoA (C18:0). It is three times more active on palmitoyl-CoA then on stearoyl-CoA. Has little activity on octanoyl-CoA (C8:0), butyryl-CoA (C4:0) or isovaleryl-CoA (5:0).,similarity:Belongs to the acyl-CoA dehydrogenase family.,tissue specificity:Ubiquitously expressed in most normal human tissues and cancer cell lines with high level of expression in heart, skeletal muscles, brain, kidney and liver.,
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